Priority 7 Stroke Prevention, Diagnosis, Pre-hospital and Hospital Care
| UNCERTAINTY: What are the processes that cause delayed changes in brain function (neurological deficit) after subarachnoid haemorrhage caused by an aneurysm? (JLA PSP Priority 7) | |
|---|---|
| Overall ranking | 7 |
| JLA question ID | 0106/7a |
| Explanatory note |
Subarachnoid haemorrhages (SAH) are often caused by a burst blood vessel in the brain (a ruptured brain aneurysm) [Ref. 7]. Aneurysmal SAH affects six to nine people per 100,000 per year, has a 35% mortality, and leaves many with lasting disabilities, often related to cognitive dysfunction [Ref. 8]. Delayed ischemic neurologic deficit (DIND) is the main preventable cause of poor outcomes in aneurysmal subarachnoid haemorrhage (SAH) patients [Ref. 9]. However, evidence is needed to understand the processes to develop treatments to prevent DIND. Ref 7: https://www.nhs.uk/conditions/subarachnoid-haemorrhage/ |
| Evidence |
No evidence identified |
| Health Research Classification System category | Stroke |
| Extra information provided by this PSP | |
|---|---|
| Original uncertainty examples | What are the mechanisms underpinning onset of delayed neurological deficit after aneurysmal subarachnoid haemorrhage? |
| Submitted by | Health/Social Care professional x 1 |
| PSP information | |
|---|---|
| PSP unique ID | 0106 |
| PSP name | Stroke prevention, diagnosis, pre-hospital and hospital care |
| Total number of uncertainties identified by this PSP. | 93 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website) |
| Date of priority setting workshop | 30th April 2021 |