Priority 9 from the Sight Loss and Vision PSP Age Related Macular Degeneration
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UNCERTAINTY: Can dietary factors, nutritional supplements, complementary therapies or lifestyle changes prevent or slow the progression of AMD? (JLA PSP Priority 9) |
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| Overall ranking | 9 |
| JLA question ID | 0014a/9 |
| Explanatory note | Reliable up-to-date systematic reviews revealed important continuing uncertainties about treatment effects at the time of the PSP |
| Evidence |
Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 6. Art. No.: CD000253. DOI: 10.1002/14651858.CD000253.pub3. Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD000254. DOI: 10.1002/14651858.CD000254.pub3 Lawrenson JG, Evans JR. Omega 3 fatty acids for preventing or slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD010015. DOI: 10.1002/14651858.CD010015.pub2 Evans JR. Ginkgo biloba extract for age-related macular degeneration. Cochrane Database of Systematic Reviews 2013, Issue 1. Art. No.: CD001775. DOI: 10.1002/14651858.CD001775.pub2. |
| Health Research Classification System category | Eye |
| Extra information provided by this PSP | |
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| Original uncertainty examples | This is an indicative uncertainty and was submitted twice, and the following submissions were merged to form this uncertainty: Which supplements can improve macular health? |
| Systematic reviews that need updating or extending | None identified |
| Systematic reviews in preparation (at time of PSP) | None identified |
| Ongoing controlled trials |
Intervention trial in early age-related macular degeneration I-TEAM NCT01694680 Walnuts and Healthy Aging WAHA NCT01634841 Effect of saffron supplementation on macular cone-mediated function in Age-related macular degeneration safAMD NCT00951288 |
| Submitted by | Carers |
| Outcomes to be measured | Change in symptoms; adverse effects or complications; acceptability to the patient; and cost |
| PSP information | |
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| PSP unique ID | 0014a |
| PSP name | Sight Loss and Vision - Age Related Macular Degeneration |
| Total number of uncertainties identified by this PSP. | 113 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website) |
| Date of priority setting workshop | April and May 2013 |