Priority 1 from the Sight Loss and Vision PSP Age Related
| UNCERTAINTY: Can a treatment to stop dry age related macular degeneration (AMD) progressing and/or developing into the wet form be devised? (JLA PSP Priority 1) | |
|---|---|
| Overall ranking | 1 |
| JLA question ID | 0014a/1 |
| Explanatory note | Reliable up-to-date systematic reviews revealed important continuing uncertainties about treatment effects at the time of the PSP |
| Evidence | Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 6. Art. No.: CD000253. DOI: 10.1002/14651858.CD000253.pub3 Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD000254. DOI: 10.1002/14651858.CD000254.pub3 Lawrenson JG, Evans JR. Omega 3 fatty acids for preventing or slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD010015. DOI: 10.1002/14651858.CD010015.pub2 Evans JR. Ginkgo biloba extract for age-related macular degeneration. Cochrane Database of Systematic Reviews 2013, Issue 1. Art. No.: CD001775. DOI: 10.1002/14651858.CD001775.pub2. |
| Health Research Classification System category | Eye |
| Extra information provided by this PSP | |
|---|---|
| Original uncertainty examples | Age Related Macular Degeneration Rank 1 Are there any known cures for dry age-related macular degeneration? Are there any prospects for treatment of dry age-related macular degeneration? Are there any treatments available for dry age-related macular degeneration? Are we getting close to a cure for both wet and dry age-related macular degeneration? Do we have any improvement in the treatment for dry age-related macular degeneration? How can dry age-related macular degeneration be treated? How can we develop an effective treatment for dry age related macular degeneration (AMD)? Why is it that (treatment for) wet age-related macular degeneration has made spectacular advances in the past few years, whereas (treatment for) dry age-related macular degeneration has made little progress? Why is there no treatment for dry age-related macular degeneration? |
| Systematic reviews that need updating or extending | None identified |
| Systematic reviews in preparation (at time of PSP) |
Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 6. Art. No.: CD000253. DOI: 10.1002/14651858.CD000253.pub3 Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD000254. DOI: 10.1002/14651858.CD000254.pub3 Lawrenson JG, Evans JR. Omega 3 fatty acids for preventing or slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD010015. DOI: 10.1002/14651858.CD010015.pub2 Evans JR. Ginkgo biloba extract for age-related macular degeneration. Cochrane Database of Systematic Reviews 2013, Issue 1. Art. No.: CD001775. DOI: 10.1002/14651858.CD001775.pub2. |
| Ongoing controlled trials | None identified |
| Submitted by | Clinicians |
| Outcomes to be measured | Change in symptoms; adverse effects or complications; acceptability to the patient; and cost |
| PSP information | |
|---|---|
| PSP unique ID |
0014a |
| PSP name | Sight Loss and Vision - Age Related Macular Degeneration |
| Total number of uncertainties identified by this PSP. | 113 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website) |
| Date of priority setting workshop | April and May 2013 |