Priority 10 from the Rare Musculoskeletal Diseases in Adulthood PSP

UNCERTAINTY: What are the best ways to prevent dental problems in people with rare metabolic bone disorders? (JLA PSP Priority 10)
Overall ranking	Joint 10th
JLA question ID	0076/10
Explanatory note	Not available for this PSP
Evidence	A prospective study reported that dental abnormalities were common in XLH, unrelated to delayed medical treatment. The authors recommended regular oral examination (Souza MA et al, Clinics (Sao Paulo) 2010, 65: 1023-1026). Small case series suggest that duration of tretment with activated vitamin D supplements may be associated with a beneficial effect on dental health (Chaussain-Miller C et al, J Pediatr 2003; 142: 324-331, Connor J et al, J Clin Endocrinol Metab 2015; 100: 3625-3632). https://onlinelibrary.wiley.com/doi/full/10.1111/j.1754-4505.2008.00070.x
Health Research Classification System category	Musculoskeletal

Extra information provided by this PSP
Original uncertainty examples	Is there any prophylactic treatment other than good oral hygiene to prevent dental infections? ~ Is there any preventive dental treatment advice? ~ Are there any procedures that a dentist might suggest to a non XLH person that would not be appropriate to the an XLH patient? eg deep cleaning, whitening?
Submitted by	Individual survey submissions categorised by Health or Social Care Professionals, Organisations representing people with rare musculoskeletal diseases, people with rare musculoskeletal diseases, relatives/carers/friends, Other. For full details of the type of submitter for each individual question, please see the spreadsheet of data held on the JLA website.

PSP information
PSP unique ID	0076
PSP name	Rare Musculoskeletal Diseases in Adulthood
Total number of uncertainties identified by this PSP.	39 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	18 June 2018