Priority 6 from the Myeloma (Canada) PSP

UNCERTAINTY: How can we prevent bone deterioration and/or repair bones that have been damaged without negative side effects (like those associated with bisphosphonates) or surgery? (JLA PSP Priority 6)
Overall ranking	6
JLA question ID	0113/6
Explanatory note	Myeloma often causes bone deterioration which results in pain and frequent fractures or breaks. The pain associated with myeloma related bone disease often persists even after the myeloma is under control. Participants would like to see ways to prevent bone deterioration or repair the bones after treatment. However, according to our evidence check, bone deterioration is often treated using bisphosphonates which have their own side effects or surgery. Therefore, better treatments are needed to manage myeloma related bone deterioration.
Evidence	No evidence identified
Health Research Classification System category	Cancer and neoplasms

Extra information provided by this PSP
Original uncertainty examples	How can bone holes be repaired or prevented? ~ What stops the deterioration of bone once treatments are done and you are in very good partial remission? ~ After the bisophosomate treatments are finished, do the bones still deteriorate? ~ Bone deterioration and pain...does it continue after you are in remission? ~ Are there ways to prevent calcium loss when strengthening bones with various meds. ~ What can one do to strengthen the bones?
Submitted by	Please see the PSP Engagement Summary on the JLA website

Extra information provided by this PSP

Original uncertainty examples

How can bone holes be repaired or prevented? ~ What stops the deterioration of bone once treatments are done and you are in very good partial remission? ~ After the bisophosomate treatments are finished, do the bones still deteriorate? ~ Bone deterioration and pain...does it continue after you are in remission? ~ Are there ways to prevent calcium loss when strengthening bones with various meds. ~ What can one do to strengthen the bones?

Submitted by

Please see the PSP Engagement Summary on the JLA website

PSP information
PSP unique ID	0113
PSP name	Myeloma (Canada)
Total number of uncertainties identified by this PSP.	59 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	28 April 2021