Priority 18 from the Myeloma (Canada) PSP

UNCERTAINTY: What is the risk to blood relatives of people with myeloma, and should they be monitored or tested routinely? (JLA PSP Priority 18)
Overall ranking	18
JLA question ID	0113/18
Explanatory note	Participants wanted research into the risk of developing myeloma for family members of persons with myeloma. Many reported relatives who also had the disease. Patients wondered about the risk to their children and wondered whether they should be monitored or tested routinely.
Evidence	No evidence identified
Health Research Classification System category	Cancer and neoplasms

Extra information provided by this PSP
Original uncertainty examples	Is there a significant familial clustering of myeloma? ~ Are there benefits to early intervention in cases where there is significant family history of the disease? ~ Should my family be tested for it? ~ Do our children need to be monitored more closely? ~ Can we consider screening the adult children of MM patients at a certain age? ~ Are family members at risk to develop? ~ How can my family prevent it? ~ Is there a test to be given family members to see if they are at risk? ~ Can my children be tested for the cancer?
Submitted by	Please see the PSP Engagement Summary on the JLA website

Extra information provided by this PSP

Original uncertainty examples

Is there a significant familial clustering of myeloma? ~ Are there benefits to early intervention in cases where there is significant family history of the disease? ~ Should my family be tested for it? ~ Do our children need to be monitored more closely? ~ Can we consider screening the adult children of MM patients at a certain age? ~ Are family members at risk to develop? ~ How can my family prevent it? ~ Is there a test to be given family members to see if they are at risk? ~ Can my children be tested for the cancer?

Submitted by

Please see the PSP Engagement Summary on the JLA website

PSP information
PSP unique ID	0113
PSP name	Myeloma (Canada)
Total number of uncertainties identified by this PSP.	59 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	28 April 2021