Priority 14 from the Myeloma (Canada) PSP

UNCERTAINTY: How can we restore myeloma patients' immune functioning (e.g., IgG treatment) so that they might resume their daily activities (e.g., travel, work) without fear of infections? (JLA PSP Priority 14)
Overall ranking	14
JLA question ID	0113/14
Explanatory note	Participants worried about the effects of myeloma treatment on patients' immune system and the resulting impact on their daily activities including working, socializing, and travelling. Some expressed a fear of infection and wanted more information on the use of IgG treatment, mask wearing, and vaccinations, as well as new treatments that do not supress the immune system.
Evidence	No evidence identified
Health Research Classification System category	Cancer and neoplasms

Extra information provided by this PSP
Original uncertainty examples	How can you disable the immune system with the drugs that slow the growth of this cancer (such as revlimid) and expect the body to be able to regenerate. ~ I worry about my future with myeloma and about where I should be going to interact with others in case of infections etc. Research on this would be good. ~ Building their Immune system the giving of a more quality of life without loss of appetite, diarrhea ~ More focus on immune system re-programming to do it's compete job which was compromised with the initial onslaught of the disease? ~ Feeling that the immune system is back to normal (not just the cancer numbers) so the it permits you to live a normal active life again (e.g. travel and contact with public) without always worrying about risks.
Submitted by	Please see the PSP Engagement Summary on the JLA website

Extra information provided by this PSP

Original uncertainty examples

How can you disable the immune system with the drugs that slow the growth of this cancer (such as revlimid) and expect the body to be able to regenerate. ~ I worry about my future with myeloma and about where I should be going to interact with others in case of infections etc. Research on this would be good. ~ Building their Immune system the giving of a more quality of life without loss of appetite, diarrhea ~ More focus on immune system re-programming to do it's compete job which was compromised with the initial onslaught of the disease? ~ Feeling that the immune system is back to normal (not just the cancer numbers) so the it permits you to live a normal active life again (e.g. travel and contact with public) without always worrying about risks.

Submitted by

Please see the PSP Engagement Summary on the JLA website

PSP information
PSP unique ID	0113
PSP name	Myeloma (Canada)
Total number of uncertainties identified by this PSP.	59 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	28 April 2021