Priority 10 from the Myeloma (Canada) PSP

UNCERTAINTY: Can we develop treatments specifically for high risk or aggressive myeloma that will improve outcomes for these patients? (JLA PSP Priority 10)
Overall ranking	10
JLA question ID	0113/10
Explanatory note	High risk or aggressive myeloma is defined by disease stage, chromosomal abnormalities, disease biology, and gene expression, and is associated with worse outcomes. Participants want to know about the current treatment options and the new treatments for patients with high risk or aggressive myeloma (including those with genetic abnormalities, deletions, etc.) that will improve outcomes for these patients?
Evidence	No evidence identified
Health Research Classification System category	Cancer and neoplasms

Extra information provided by this PSP
Original uncertainty examples	Are there individual drugs that can be isolated to the treatment of specific myeloma conditions such as high risk factors? ~ How can outcomes be better for those with high risk myeloma (genetic abnormalities, deletions, etc) ~ More research for specific treatments for high risk myeloma Results of larger studies broken down to show results for high risk patients separately from regular myeloma patients ~ What treatments are most effective for those living with a P53 diagnosis.
Submitted by	Please see the PSP Engagement Summary on the JLA website

Extra information provided by this PSP

Original uncertainty examples

Are there individual drugs that can be isolated to the treatment of specific myeloma conditions such as high risk factors? ~ How can outcomes be better for those with high risk myeloma (genetic abnormalities, deletions, etc) ~ More research for specific treatments for high risk myeloma Results of larger studies broken down to show results for high risk patients separately from regular myeloma patients ~ What treatments are most effective for those living with a P53 diagnosis.

Submitted by

Please see the PSP Engagement Summary on the JLA website

PSP information
PSP unique ID	0113
PSP name	Myeloma (Canada)
Total number of uncertainties identified by this PSP.	59 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	28 April 2021