Priority 3 from the Multiple Sclerosis PSP
| UNCERTAINTY: Which treatments are effective for fatigue in people with multiple sclerosis? (JLA PSP Priority 3) | |
|---|---|
| Overall ranking | 3 |
| JLA question ID | 0016/3 |
| Explanatory note | Reliable up-to-date systematic reviews have revealed important continuing uncertainties about treatment effects |
| Evidence |
Tejani AM, Wasdell M, Spiwak R, Rowell G, Nathwani S. Carnitine for fatigue in multiple sclerosis. Cochrane Database of Systematic Reviews 2012, Issue 5. Art. No.: CD007280. DOI: 10.1002/14651858.CD007280.pub3. Payne C, Wiffen PJ, Martin S. Interventions for fatigue and weight loss in adults with advanced progressive illness. Cochrane Database of Systematic Reviews 2012, Issue 1. Art. No.: CD008427. DOI: 10.1002/14651858.CD008427.pub2. |
| Systematic reviews that need extending or updating |
No reviews found |
| Systematic reviews in preparation |
Heine M, Rietberg MB, van Wegen EEH, Port IVD, Kwakkel G. Exercise therapy for fatigue in multiple sclerosis (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 7. Art. No.: CD009956. DOI: 10.1002/14651858.CD009956. |
| Ongoing controlled trials |
TREating FAtigue in Multiple Sclerosis: Energy conservation management TREFAMS-E ISRCTN82353628 TREating FAtigue in Multiple Sclerosis: Aerobic training TREFAMS-A ISRCTN69520623 TREating FAtigue in Multiple Sclerosis: Cognitive behavioural therapy TREFAMS-C ISRCTN58583714 |
| Health Research Classification System category | Neurological |
| Extra information provided by this PSP | |
|---|---|
| Original uncertainty examples | No examples provided. This is an indicative uncertainty and several submissions were merged to form this one. |
| Submitted by | 16 patients ~ 6 carers ~ 9 clinicians |
| Outcomes to be measured | Management and or change of multiple sclerosis symptoms; adverse effects or complications; acceptability to patients or carers; time to return to work or normal activity; time in hospital and or needing health or social care services; health related quality of life; and costs. |
| PSP information | |
|---|---|
| PSP unique ID | 0016 |
| PSP name | Multiple Sclerosis |
| Total number of uncertainties identified by this PSP. | 82 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website) |
| Date of priority setting workshop | July 2013 |