Priority 15 from the Mitochondrial Disease PSP

UNCERTAINTY: Is there a way to predict who will become ill with mitochondrial disease, and whose symptoms will be worse? (JLA PSP Priority 15)
Overall ranking	15
JLA question ID	0095/15
Explanatory note	Not available
Evidence	None identified
Health Research Classification System category	Metabolic and Endocrine

Extra information provided by this PSP
Original uncertainty examples	LHON - how can we predict who will get clinical disease ~ What are the chances of symptom progression depending on % of mutation? ~ Is there a way to predict the severity of the disease in infants of parents with Mitochondrial Disease? ~ Can a test be developed that predicts the chances of a carrier going blind? ~ Is there a benefit to establishing percentage mutation load in a particular patient? ~ Understanding of predictive factors
Submitted by	3 x Healthcare Professional, 2 x Patient, 1 x Carer

Extra information provided by this PSP

Original uncertainty examples

LHON - how can we predict who will get clinical disease ~ What are the chances of symptom progression depending on % of mutation? ~ Is there a way to predict the severity of the disease in infants of parents with Mitochondrial Disease? ~ Can a test be developed that predicts the chances of a carrier going blind? ~ Is there a benefit to establishing percentage mutation load in a particular patient? ~ Understanding of predictive factors

Submitted by

3 x Healthcare Professional, 2 x Patient, 1 x Carer

PSP information
PSP unique ID	0095
PSP name	Mitochondrial Disease
Total number of uncertainties identified by this PSP.	42 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	19 January 2020