Priority 1 from the Miscarriage PSP

UNCERTAINTY: What are the effective interventions to prevent miscarriage, threatened miscarriage and recurrent miscarriage? (e.g. lifestyle, vitamins, aspirin, early scans, HCG, dopamine agonists, progestogen, polytherapy, steroids, oestrogen, metformin, anticoagulants, intravenous immunoglobulin, intralipid and anti-tnf alpha) (JLA PSP Priority 1)
Overall ranking	1
JLA question ID	0053/1
Explanatory note	Examples of original survey submissions: What are the effective interventions to prevent miscarriage?; Is progesterone effective in preventing a miscarriage?; Which treatments are effective in preventing recurrent miscarriage?
Evidence	Balogun OO, da Silva Lopes K, Ota E, Takemoto Y, Rumbold A, Takegata M, Mori R. Vitamin supplementation for preventing miscarriage. Cochrane Database of Systematic Reviews 2016, Issue 5. Art. No.: CD004073. DOI: 10.1002/14651858.CD004073.pub4. Lim CED, Ho KKW, Cheng NCL, Wong FWS. Combined oestrogen and progesterone for preventing miscarriage. Cochrane Database of Systematic Reviews 2013, Issue 9. Art. No.: CD009278. DOI: 10.1002/14651858.CD009278.pub2. Wong LF, Porter TF, Scott JR. Immunotherapy for recurrent miscarriage. Cochrane Database of Systematic Reviews 2014, Issue 10. Art. No.: CD000112. DOI: 10.1002/14651858.CD000112.pub3. Wariki WMV, Goto Y, Ota E, Mori R. Cyclo-oxygenase (COX) inhibitors for threatened miscarriage (Protocol). Cochrane Database of Systematic Reviews 2014, Issue 9. Art. No.: CD011310. DOI: 10.1002/14651858.CD011310. de Jong PG, Kaandorp S, Di Nisio M, Goddijn M, Middeldorp S. Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia. Cochrane Database of Systematic Reviews 2014, Issue 7. Art. No.: CD004734. DOI: 10.1002/14651858.CD004734.pub4. Haas DM, Ramsey PS. Progestogen for preventing miscarriage. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD003511. DOI: 10.1002/14651858.CD003511.pub3. Wahabi HA, Fayed AA, Esmaeil SA, Al Zeidan RA. Progestogen for treating threatened miscarriage. Cochrane Database of Systematic Reviews 2011, Issue 12. Art. No.: CD005943. DOI: 10.1002/14651858.CD005943.pub4. Morley LC, Simpson N, Tang T. Human chorionic gonadotrophin (hCG) for preventing miscarriage. Cochrane Database of Systematic Reviews 2013, Issue 1. Art. No.: CD008611. DOI: 10.1002/14651858.CD008611.pub2. Devaseelan P, Fogarty PP, Regan L. Human chorionic gonadotrophin for threatened miscarriage. Cochrane Database of Systematic Reviews 2010, Issue 5. Art. No.: CD007422. DOI: 10.1002/14651858.CD007422.pub2. Empson MB, Lassere M, Craig JC, Scott JR. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database of Systematic Reviews 2005, Issue 2. Art. No.: CD002859. DOI: 10.1002/14651858.CD002859.pub2. Bamigboye AA, Morris J. Oestrogen supplementation, mainly diethylstilbestrol, for preventing miscarriages and other adverse pregnancy outcomes. Cochrane Database of Systematic Reviews 2003, Issue 3. Art. No.: CD004353. DOI: 10.1002/14651858.CD004353.
Health Research Classification System category	Reproduction

Extra information provided by this PSP
Submitted by	53 professionals~240 women~3 charities~4 family, friends or colleagues~2 professional bodies

PSP information
PSP unique ID	0053
PSP name	Miscarriage
Total number of uncertainties identified by this PSP.	58 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	14 October 2016