Priority 1 from the Mesothelioma PSP
| UNCERTAINTY: Does boosting the immune system (using new agents such as PD-1 or PD-L1) improve response and survival rates for mesothelioma patients? (JLA PSP Priority 1) | |
|---|---|
| Overall ranking | 1 |
| JLA question ID | 0025/1 |
| Explanatory note | Not available for this PSP |
| Evidence | Ongoing study - A Randomized Study of Adjuvant WT-1 Analog Peptide Vaccine in Patients With Malignant Pleural Mesothelioma (MPM) After Completion of Combined Modality Therapy. |
| Health Research Classification System category | Cancer |
| Extra information provided by this PSP | |
|---|---|
| Original uncertainty examples | Anti-oxidants/vitamins in large doses have been given to 'long' survivors of meso (in USA). Why not in UK? (to boost immune system) ~ Can the immune system be stimulated to fight mesothelioma? ~ Again no one seems to be able to tell me if extra vitamin tablets will help his immune system? I now have started to to give him BioCare multivitamins to help his immune system after a lot of sickness nausea and not wanting to eat. He has lost over two stones. ~ What research is taking place into ways to strengthen the immune system to fight this disease (ie, acupuncture, nutrition, exercise, meditation, positive outlook)? I have been having weekly acupuncture since diagnosis and scans show tumour is shrinking slightly. I am doing all of the above to some degree and would like to know which is the most useful. ~ immune system too low to have any treatment |
| Comparison | None identified |
| Submitted by | Bereaved ~ Patient x2 ~ Carer x2 |
| Outcomes to be measured | Survival |
| PSP information | |
|---|---|
| PSP unique ID | 0025 |
| PSP name | Mesothelioma |
| Total number of uncertainties identified by this PSP. | 53 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website) |
| Date of priority setting workshop | 16 December 2014 |