Priority 12 from the Kidney Transplant PSP

UNCERTAINTY: For which patients is transplantation not suitable (considering factors such as age, body mass index, history of cancer, co-morbidities)?
Overall ranking	Priority questions agreed on but not put in ranked order
JLA question ID	0037/12
Explanatory note	Not available for this PSP
Evidence	Existing Systematic Reviews: Dr Chris Dudley & Dr Paul Harden. Clinical Practice Guidelines: Module 4, Assessment for Renal Transplantation. UK Renal Association 4th Edition, 2008 ~ Daniel Abramowicz, Wim Van Biesen, Pierre Cochat, Raymond Vanholder. ERBP Guideline on kidney donor and recipient evaluation and perioperative care ~ The Transplantation Society of Australia and New Zealand (TSANZ) Organ Transplantation From Deceased Donors: Consensus statement in eligibility criteria and allocation protocols. Version 1.1 23 June 2011 ~ Blosser CD, Huverserian A, Bloom RD, Abt PD, Goral S, Thomasson A, Shults J, Reese PP. Age, exclusion criteria, and generalizability of randomized trials enrolling kidney transplant recipients. Transplantation. 2011;91(8):858-63 Existing Randomised Controlled Trials: Macauley R. Weighing potential candidates for kidney transplant: the ethics of exclusion for elevated body mass index. Prog Transplant. 2012 Dec;22(4):369-73. PMID: 23187054 ~ Impedovo SV, Ditonno P, Ricapito V, et al. Advanced age is not an exclusion criterion for kidney transplantation. Transplant Proc. 2013 Sep;45(7):2650-3. doi: 10.1016/j.transproceed.2013.08.003. PMID: 24034014 ~ Ahmadnia H, Shamsa A, Yarmohammadi A, Darabi M, Asl Zare M. Kidney transplantation in older adults: does age affect graft survival? Urol J. 2005 Spring;2(2):93-6. PubMed PMID: 17629878
Health Research Classification System category	Renal and Urogenital

Extra information provided by this PSP
Original uncertainty examples	How do you select suitable patients for transplant? Does your overall health & fitness impact on suitability for transplant? Is it possible to define, in more absolute terms exclusion and inclusion criteria? This relates particularly to BMI, age, concordance, and anaesthetic assessment.
Comparison	Mixed or complex
Submitted by	Patients x 1 Clinicians x 2
Outcomes to be measured	Patient and graft survival, graft function, adverse events

PSP information
PSP unique ID	0037
PSP name	Kidney Transplant
Total number of uncertainties identified by this PSP.	90 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	3 February 2016