Priority 8 from the Hyperemesis Gravidarum PSP

UNCERTAINTY: What are the immediate and long term, physical, mental and social consequences and complications of hyperemesis gravidarum (including malnutrition and dehydration) on the pregnant person's body. (ie. Metabolic impact, DVT, depression, effects of dehydration) (JLA PSP Priority 8)
Overall ranking	8
JLA question ID	0090/8
Explanatory note	Not available for this PSP
Evidence	Pyschological morbidity has been demonstrated with systematic review: Mitchell-Jones, N., et al. (2017). "Psychological morbidity associated with hyperemesis gravidarum: a systematic review and meta-analysis." Bjog-an International Journal of Obstetrics and Gynaecology 124(1): 20-30. A myriad of other consequences and complications have been identified in the literature but no systematic review.
Health Research Classification System category	Reproductive health and childbirth

Extra information provided by this PSP
Original uncertainty examples	What are the most common complications of HG? ~ How can we raise the risk of embolism, so women know when to seek help? ~ What are the longterm effects of HG for mother and baby? ~ Metabolic impact of hyperemesis during and after pregnancy? ~ What are the long tern effects of HG (i.e. up to 5 years after the pregnancy)? ~ Is HG linked to higher rates of postnatal depression, family breakdown, and decisions not to have any other children? ~ How many HG sufferers had to stop working prematurely?
Submitted by	Patients x 95 ~ Healthcare professionals x 12 ~ Carers x 5 ~ Offspring x 12 ~ Organisational representatives x 2 ~ Unknown x 6

Extra information provided by this PSP

Original uncertainty examples

What are the most common complications of HG? ~ How can we raise the risk of embolism, so women know when to seek help? ~ What are the longterm effects of HG for mother and baby? ~ Metabolic impact of hyperemesis during and after pregnancy? ~ What are the long tern effects of HG (i.e. up to 5 years after the pregnancy)? ~ Is HG linked to higher rates of postnatal depression, family breakdown, and decisions not to have any other children? ~ How many HG sufferers had to stop working prematurely?

Submitted by

Patients x 95 ~ Healthcare professionals x 12 ~ Carers x 5 ~ Offspring x 12 ~ Organisational representatives x 2 ~ Unknown x 6

PSP information
PSP unique ID	0090
PSP name	Hyperemesis Gravidarum
Total number of uncertainties identified by this PSP.	65 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	9 October 2019