Priority 16 from the Contraception PSP
| UNCERTAINTY: Do progestogens used alone or in combined hormonal contraception interact with anti-depressants? (JLA PSP Priority 16) | |
|---|---|
| Overall ranking | 16 |
| JLA question ID | 0049/16 |
| Explanatory note | Depression/anxiety affects about 1 in 7 women in the UK. The effects of hormonal contraception on mood in all was raised by many users and healthcare professionals, this priority is the effect on a -women with on treatment which is a specific group but which overlaps with the research priority 2 and the NICE LARC guideline research recommendations “Most women will need to use contraception for more than 30 years… a woman's choice and acceptance of LARC may be influenced by potential health dis-benefits (side effects and risks) as well as non contraceptive benefits of LARC.. The NATSAL3 survey DOI: http://dx.doi.org/10.1016/S0140-6736(13)62071-1,found depression to be associated with a doubling of the risk of unplanned pregnancy. |
| Evidence |
Association of Hormonal Contraception with Depression. Skovlund CW, Mørch LS, Kessing LV, et al .JAMA Psychiatry. 28 September 2016. doi:10.1001/jamapsychiatry.2016.2387 Drug interactions between hormonal contraceptives and psychotropic drugs: a systematic review. Erin N. Berry-Bibee, Myong-Jin Kim, Katharine B. Simmons, Naomi K. Tepper, Halley E.M. Riley, H. Pamela Pagano, Kathryn M. Curtis. Contraception, Vol. 94, Issue 6, p650–667. Published online: July 18, 2016. PreviewFull-Text HTMLPDF Co-administration of St. John's wort and hormonal contraceptives: a systematic review. Erin N. Berry-Bibee, Myong-Jin Kim, Naomi K. Tepper, Halley E.M. Riley, Kathryn M. Curtis. Contraception, Vol. 94, Issue 6, p668–677. Published online: July 18, 2016. Pagano HP, Zapata LB, Berry-Bibee EN, et al. Safety of hormonal contraception and intrauterine devices among women with depressive and bipolar disorders: a systematic review. Contraception. 27 June 2016. pii: S0010-7824(16)30133-0. DOI:http://dx.doi.org/10.1016/j.contraception.2016.06.012 |
| Health Research Classification System category | Reproductive Health and Childbirth |
| Extra information provided by this PSP | |
|---|---|
| Original uncertainty examples |
“Contraception (all) side effects when taken with other medicines - in particular anti-depressants (flouexetine, citalopram)”(Both) |
| Submitted by | Healthcare Professionals x 0~Patients x 0~Both x 2 |
| PSP information | |
|---|---|
| PSP unique ID | 0049 |
| PSP name | Contraception |
| Total number of uncertainties identified by this PSP. | 57 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website) |
| Date of priority setting workshop | 21 April 2017 |