Priority 5 from the Bleeding Disorder PSP
| UNCERTAINTY: What is the relationship between immune thrombocytopenic purpura (ITP) and fatigue? (JLA PSP Priority 5) | |
|---|---|
| Overall ranking | 5 |
| JLA question ID | 0078/5 |
| Explanatory note |
Fatigue is a most common complaint made by patients with ITP. The degree of fatigue varies from patient to patient and in severe cases can be extremely debilitating and can lead to the patients being unable to hold down employment. There have been many investigations to determine if fatigue is a side effect of ITP, all of which have proved positive. However, there has been no research into what causes fatigue in patients with ITP and the relationship to a reduction of platelets in the blood either due to low platelet production; platelet destruction or the effect of other organs within the body. |
| Evidence | No systematic review. One observational study: Newton, J. L., et al. (2011). "Fatigue in adult patients with primary immune thrombocytopenia." European Journal of Haematology 86(5): 420-429. 10.1111/j.1600-0609.2011.01587.x |
| Health Research Classification System category | Blood |
| Extra information provided by this PSP | |
|---|---|
| Original uncertainty examples | Why is fatigue/tiredness still NOT fully recognised as a symptom of ITP (Immune Thrombocytopenia) ? ~ How can the fatigue associated with bleeding disorders be ameliorated or eliminated? ~ Will tiredness ever be properly proven to be a symptom of ITP? |
| Submitted by | Not available |
| PSP information | |
|---|---|
| PSP unique ID | 0078 |
| PSP name | Bleeding Disorders |
| Total number of uncertainties identified by this PSP. | 66 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website) |
| Date of priority setting workshop | 7 July 2018 |