Vascular Conditions

Perineural Local Anaesthetic Catheter aftEr Major lowEr limb amputatioN Trial (PLACEMENT)

Addressing priorities 2, 3 and 4 of the Amputation Top 10, as well as a top priority of the Anaesthesia and Perioperative Care PSP: NIHR research in progress

This study will test a method for reducing pain after leg amputation. It involves the surgeon placing a tiny tube, called a 'perineural catheter', next to the main nerve which is cut during surgery. Local anaesthetic is slowly pumped into the tube for five days. Putting it in and taking it out is easy and problems are rare. It can replace some (or all) of the morphine usually needed. It may also reduce phantom pain. The study will be a 'randomised' trial. This means patients will be randomly chosen to either have surgery with, or without, the tube. Everything else will be the same. The amount of pain will then be compared between those who did and those who did not have the tube.

A randomised controlled trial assessing the clinical and cost-effectiveness of Endovascular vs. Open revascularisation in severe oCClusive aorto-iliac disease. The EVOCC trial.

Addressing priorities from the Vascular Conditions PSP: NIHR research in progress

Paclitaxel or sirolimus coated balloons for ArterioVEnous fistulas (PAVE-2 trial)

Addressing priorities in the Access Top 10: NIHR research in progress

Identifying the most clinically- and cost-effective exercise prescription for patients with intermittent claudication (MAXIMISE): a component network meta-analysis to answer a James Lind Alliance priority research question.

Addressing priorities from the Vascular Conditions PSP: NIHR research in progress