Pernicious Anaemia PSP Question Verification form

The purpose of this Question Verification Form is to enable Priority Setting Partnerships (PSPs) to describe clearly how they checked that their questions were unanswered, before starting the interim prioritisation stage of the process.

The JLA requires PSPs to be transparent and accountable in defining their own scope and evidence checking process. This will enable researchers and other stakeholders to understand how individual PSPs decided that their questions were unanswered, and any limitations of their evidence checking.

Name of the PSP

Pernicious Anaemia

Please describe the scope of the PSP

The scope of the Pernicious Anaemia PSP is uncertainties about the Cause, Diagnosis, Treatment and Care of Pernicious Anaemia, including:

Identifying the uncertainties with the clinical definition of Pernicious Anaemia
Identifying the uncertainties with the tests used to Diagnose Vitamin B12 Deficiency
Identifying the uncertainties with the tests to Diagnose Pernicious Anaemia
Identifying the uncertainties with the current management replacement therapy regimen
Identifying the uncertainties with other replacement therapy delivery methods

Please provide a brief overview of your approach to checking whether the questions were unanswered

Given the limited amount of research in this area, we included reviews published in the last ten years. We applied the JLA standard of seeking relevant systematic reviews.

Please list the type(s) of evidence you used to verify your questions as unanswered

Systematic Reviews

Please list the sources that you searched in order to identify that evidence

Cochrane
PubMed
Google Scholar
British Society for Haematology Guidelines 2014

What search terms did you use?

‘pernicious anaemia/ anemia’ and ‘systematic review’

Please describe the parameters of the search (eg time limits, excluded sources, country/language) and the rationale for any limitations

Systematic reviews were excluded if they were:

more than ten years’ old
not from the UK
focused on B12 Deficiency rather than pernicious anaemia

Names of individuals who undertook the evidence checking

Kristina Staley

On what date was the question verification process completed?

14 July 2021